[HTML][HTML] Organoid and spheroid tumor models: Techniques and applications

S Gunti, ATK Hoke, KP Vu, NR London Jr - Cancers, 2021 - mdpi.com
… Organoids and spheroids are different 3D cell culture models … such applications as cancer
cell migration and invasion [32]. … organotypic tumor spheroids retaining autologous immune …

Modelling Metastasis in Neuroblastoma: 3D Culture Assays of Local Tumour Invasion

C Gavin - 2022 - repository.rcsi.com
culture and 3D invasion assays as a valuable tool to discover the molecular mechanisms
controlling local invasioninvasion utilise multicellular tumour spheroids (MCTS); aggregates of …

[HTML][HTML] Modeling human brain tumors and the microenvironment using induced pluripotent stem cells

ZI Khamis, DB Sarker, Y Xue, N Al-Akkary, VD James… - Cancers, 2023 - mdpi.com
… To more accurately model the human brain, a 3D culture … derived GSC spheroids exhibited
different invasion potential that … cells, this forms the basis for establishing autologous invasion

Developing bioinspired three-dimensional models of brain cancer to evaluate tumor-homing neural stem cell therapy

AG Carey-Ewend, SB Hagler, HN Bomba… - … Engineering Part A, 2021 - liebertpub.com
… tissue culture hood and incubated overnight in 3D cell culture … when designing redosing
studies and tracking tumor invasion. … In the case of autologous NSC-based therapies, a method …

[HTML][HTML] Microglia-mediated drug substance transfer promotes chemoresistance in brain tumors: insights from an in vitro co-culture model using GCV/Tk prodrug …

SY Wu, WJ Yu, TY Chien, YA Ren, CS Chen… - Cancer Cell …, 2024 - Springer
… system was used to mimic the microglia dominating tumor stroma in the tumor invasion
render brain tumor cells to form a spheroid structure rapidly under normal cell culture conditions. …

[HTML][HTML] Glioblastoma organoids: pre-clinical applications and challenges in the context of immunotherapy

E Klein, AC Hau, A Oudin, A Golebiewska… - Frontiers in …, 2020 - frontiersin.org
… For Glioblastoma (GBM), the most severe form of brain cancer … termed ‘organotypic tumor
spheroids’, these cultures fulfill the … vivo co-cultures of organoids with autologous PBMCs have …

[HTML][HTML] Cancer spheroids and organoids as novel tools for research and therapy: state of the art and challenges to guide precision medicine

S El Harane, B Zidi, N El Harane, KH Krause, T Matthes… - Cells, 2023 - mdpi.com
… addition of non-autologous stromal/immune cells to 3D culture is … Similarly, brain tumor
spheroids were formed by seeding … into Matrigel to monitor the invasion of the extracellular matrix. …

[HTML][HTML] GD2 CAR T cells against human glioblastoma

M Prapa, C Chiavelli, G Golinelli, G Grisendi… - NPJ precision …, 2021 - nature.com
… on the delivery route for targeting brain tumors, we compared … C6) co-cultures with either
autologous or allogeneic GD2 … we used a biocompatible 3D cell culture device that allows a …

Redox modulation by plant polyphenols targeting vitagenes for chemoprevention and therapy: Relevance to novel anti-cancer interventions and mini-brain organoid …

M Scuto, ML Ontario, AT Salinaro, I Caligiuri… - Free Radical Biology …, 2022 - Elsevier
… mini-brain tumor organoids to study human carcinogenesis, … promoting cancer initiation,
proliferation, invasion and … compared to autologous para-cancerous brain tissues [43]. The …

[HTML][HTML] Central nervous system tumors and three-dimensional cell biology: Current and future perspectives in modeling

Z Abou-Mrad, JB Gharios, MM Moubarak… - World Journal of Stem …, 2021 - ncbi.nlm.nih.gov
… to serve as screening tools for studying brain tumor growth and … hepatocellular carcinoma
spheroids in which a 3D co-culture … Cytolytic effects of autologous lymphokine-activated killer …